Reactome | PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane

Schema > Reaction > Entries

PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806248] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId	1676149
displayName	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Homo sapiens [Reaction:R-HSA-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1676004] The lipid phosphatase activity of PTEN is critical for its tumor supressor function [LiteratureReference:1675887] Membrane-binding and activation mechanism of PTEN [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association [LiteratureReference:8948103] Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
orthologousEvent	[Reaction:R-MMU-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Mus musculus [Reaction:R-RNO-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Rattus norvegicus [Reaction:R-CFA-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Canis familiaris [Reaction:R-SCE-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-BTA-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Bos taurus [Reaction:R-DDI-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Dictyostelium discoideum [Reaction:R-CEL-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Gallus gallus [Reaction:R-XTR-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Danio rerio [Reaction:R-SSC-1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - Sus scrofa
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
precedingEvent	[Reaction:R-HSA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676149
summation	[Summation:1675876] At the plasma membrane, phosphatidylinositol-3,4,5-trisphosp...
updateTrackers	[UpdateTracker:9782059] Update Tracker - [Reaction:1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - v59:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782059] Update Tracker - [Reaction:1676149] PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane - v59:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane
(precedingEvent)	[Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-HSA-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane [Reaction:R-HSA-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane

Cite Us!