Reactome | PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane

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PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806174] phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId	1676164
displayName	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-6809975] PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane - Homo sapiens [Reaction:R-HSA-6809325] PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676134] PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane - Homo sapiens [Reaction:R-HSA-1675994] PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1676179] The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase [LiteratureReference:1676120] The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family [LiteratureReference:1675803] The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
orthologousEvent	[Reaction:R-MMU-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Mus musculus [Reaction:R-RNO-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Rattus norvegicus [Reaction:R-CFA-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Canis familiaris [Reaction:R-BTA-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Bos taurus [Reaction:R-CEL-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Gallus gallus [Reaction:R-XTR-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Danio rerio [Reaction:R-SSC-1676164] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane - Sus scrofa
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806276] PI3P [plasma membrane]
precedingEvent	[Reaction:R-HSA-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane - Homo sapiens [Reaction:R-HSA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676164
summation	[Summation:1675897] At the plasma membrane, type I and type II inositol-3,4-bisp...

Referrals

(hasEvent)

[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane

(precedingEvent)

[Reaction:R-HSA-6809975] PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane
[Reaction:R-HSA-6809325] PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane
[Reaction:R-HSA-1676134] PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
[Reaction:R-HSA-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
[Reaction:R-HSA-1675994] PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane

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