Reactome | PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

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PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10939249] phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity of INPP5(2) [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
dbId	10939251
displayName	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
eventOf	[Pathway:R-PFA-1660499] Synthesis of PIPs at the plasma membrane - Plasmodium falciparum
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
name	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
precedingEvent	[Reaction:R-PFA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Plasmodium falciparum
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-1675949
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-1660499] Synthesis of PIPs at the plasma membrane
(precedingEvent)	[Reaction:R-PFA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
(inferredTo)	[Reaction:R-HSA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

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