Reactome | Energy dependent regulation of mTOR by LKB1-AMPK

Schema > Pathway > Entries

Energy dependent regulation of mTOR by LKB1-AMPK Show undefined attributes

authored	[InstanceEdit:380973] Katajisto, P, Makela, T, Wu, J, 2008-11-19
created	[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
crossReference	[DatabaseIdentifier:12325582] BioModels Database:BIOMD0000000582
dbId	380972
displayName	Energy dependent regulation of mTOR by LKB1-AMPK
doi	10.3180/REACT_21387.1
edited	[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
eventOf	[Pathway:R-HSA-165159] MTOR signalling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:171508] regulation of cell cycle
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Homo sapiens [Reaction:R-HSA-200421] Activation of cytosolic AMPK by phosphorylation - Homo sapiens [Reaction:R-HSA-380949] AMPK is dephosphorylated - Homo sapiens [Reaction:R-HSA-380930] Phosphorylated AMPK binds AMP - Homo sapiens [Reaction:R-HSA-447074] AMPK phosphorylates Raptor in the mTORC1 complex - Homo sapiens [Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2 - Homo sapiens [Reaction:R-HSA-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:388745] The LKB1 tumor suppressor kinase in human disease [LiteratureReference:381835] AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy [LiteratureReference:381853] Defining the role of mTOR in cancer
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Energy dependent regulation of mTOR by LKB1-AMPK
orthologousEvent	[Pathway:R-MMU-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Mus musculus [Pathway:R-SCE-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Saccharomyces cerevisiae [Pathway:R-SPO-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Schizosaccharomyces pombe [Pathway:R-DDI-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Dictyostelium discoideum [Pathway:R-CEL-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Caenorhabditis elegans [Pathway:R-DME-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Drosophila melanogaster [Pathway:R-GGA-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Gallus gallus [Pathway:R-XTR-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Xenopus tropicalis [Pathway:R-DRE-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Danio rerio [Pathway:R-SSC-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Sus scrofa [Pathway:R-BTA-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Bos taurus [Pathway:R-CFA-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Canis familiaris [Pathway:R-RNO-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Rattus norvegicus
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-380972
summation	[Summation:388748] Upon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 p...

Referrals

(hasEncapsulatedEvent)	[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(hasEvent)	[Pathway:R-HSA-165159] MTOR signalling

Cite Us!