Reactome | Formation of Ragulator complex

Schema > Reaction > Entries

Formation of Ragulator complex Show undefined attributes

authored	[InstanceEdit:5671717] Jupe, Steve, 2015-02-02
category	binding
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:5653922] Jupe, Steve, 2014-12-03
dbId	5653936
displayName	Formation of Ragulator complex
edited	[InstanceEdit:5693051] Jupe, Steve, 2015-05-13
eventOf	[Pathway:R-HSA-165159] MTOR signalling - Homo sapiens
followingEvent	[Reaction:R-HSA-5653974] Ragulator binds Rag dimers - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5653582] LAMTOR1 [lysosomal membrane] [EntityWithAccessionedSequence:R-HSA-5653583] LAMTOR2 [lysosomal membrane] [EntityWithAccessionedSequence:R-HSA-5653581] LAMTOR3 [lysosomal membrane] [EntityWithAccessionedSequence:R-HSA-5655432] LAMTOR4 [lysosomal membrane] [EntityWithAccessionedSequence:R-HSA-5655441] LAMTOR5 [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5653913] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids [LiteratureReference:5655439] Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Formation of Ragulator complex
orthologousEvent	[Reaction:R-DDI-5653936] Formation of Ragulator complex - Dictyostelium discoideum [Reaction:R-DME-5653936] Formation of Ragulator complex - Drosophila melanogaster [Reaction:R-XTR-5653936] Formation of Ragulator complex - Xenopus tropicalis [Reaction:R-DRE-5653936] Formation of Ragulator complex - Danio rerio [Reaction:R-BTA-5653936] Formation of Ragulator complex - Bos taurus [Reaction:R-CFA-5653936] Formation of Ragulator complex - Canis familiaris [Reaction:R-RNO-5653936] Formation of Ragulator complex - Rattus norvegicus [Reaction:R-MMU-5653936] Formation of Ragulator complex - Mus musculus
output	[Complex:R-HSA-5653921] Ragulator [lysosomal membrane]
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5653936
summation	[Summation:5653918] A complex of LAMTOR1 to 5, known as Ragulator, interacts wit...
updateTrackers	[UpdateTracker:9984683] Update Tracker - [Reaction:5653936] Formation of Ragulator complex - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984683] Update Tracker - [Reaction:5653936] Formation of Ragulator complex - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-165159] MTOR signalling
(precedingEvent)	[Reaction:R-HSA-5653974] Ragulator binds Rag dimers