Reactome | mTORC1 phosphorylates AKT1S1

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mTORC1 phosphorylates AKT1S1 Show undefined attributes

authored	[InstanceEdit:5671717] Jupe, Steve, 2015-02-02
catalystActivity	[CatalystActivity:165690] protein serine/threonine kinase activity of Active mTORC1 complex [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:5672806] Jupe, Steve, 2015-02-06
dbId	5672828
displayName	mTORC1 phosphorylates AKT1S1
edited	[InstanceEdit:5693051] Jupe, Steve, 2015-05-13
eventOf	[Pathway:R-HSA-165159] MTOR signalling - Homo sapiens
followingEvent	[Reaction:R-HSA-5672824] Phosphorylated AKT1S1 binds YWHAB - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-377124] p-T246-AKT1S1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:377225] The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 [LiteratureReference:377103] Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation [LiteratureReference:9975216] mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	mTORC1 phosphorylates AKT1S1
orthologousEvent	[Reaction:R-DME-5672828] mTORC1 phosphorylates AKT1S1 - Drosophila melanogaster [Reaction:R-XTR-5672828] mTORC1 phosphorylates AKT1S1 - Xenopus tropicalis [Reaction:R-DRE-5672828] mTORC1 phosphorylates AKT1S1 - Danio rerio [Reaction:R-SSC-5672828] mTORC1 phosphorylates AKT1S1 - Sus scrofa [Reaction:R-BTA-5672828] mTORC1 phosphorylates AKT1S1 - Bos taurus [Reaction:R-CFA-5672828] mTORC1 phosphorylates AKT1S1 - Canis familiaris [Reaction:R-RNO-5672828] mTORC1 phosphorylates AKT1S1 - Rattus norvegicus [Reaction:R-MMU-5672828] mTORC1 phosphorylates AKT1S1 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-200163] p-S183,S221,T246-AKT1S1 [cytosol]
precedingEvent	[Reaction:R-HSA-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-165680] Formation of active mTORC1 complex - Homo sapiens [Reaction:R-HSA-9975250] PGK1 phosphorylates AKT1S1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672828
summation	[Summation:5672790] AKT1S1 (PRAS40) is phosphorylated by AKT at Thr246, which...
updateTrackers	[UpdateTracker:9984622] Update Tracker - [Reaction:5672828] mTORC1 phosphorylates AKT1S1 - v96:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9984622] Update Tracker - [Reaction:5672828] mTORC1 phosphorylates AKT1S1 - v96:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-5672824] Phosphorylated AKT1S1 binds YWHAB
(hasEvent)	[Pathway:R-HSA-165159] MTOR signalling