Reactome | MTOR signalling

Schema > Pathway > Entries

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107098
displayName	MTOR signalling
eventOf	[TopLevelPathway:R-SCE-162582] Signal Transduction - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SCE-165195] GTP loading by Rheb - Saccharomyces cerevisiae [Reaction:R-SCE-5653957] Rag dimer formation - Saccharomyces cerevisiae [Pathway:R-SCE-166208] mTORC1-mediated signalling - Saccharomyces cerevisiae [Pathway:R-SCE-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-165159] MTOR signalling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	MTOR signalling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-165159
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-SCE-162582] Signal Transduction
(hasEncapsulatedEvent)	[Pathway:R-SCE-1257604] PIP3 activates AKT signaling [Pathway:R-SCE-74752] Signaling by Insulin receptor [Pathway:R-SCE-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [Pathway:R-SCE-380972] Energy dependent regulation of mTOR by LKB1-AMPK
(inferredTo)	[Pathway:R-HSA-165159] MTOR signalling