Reactome | ENPP7 hydrolyzes sphingomyelin

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ENPP7 hydrolyzes sphingomyelin Show undefined attributes

authored	[InstanceEdit:1640162] Jassal, B, 2011-10-10
catalystActivity	[CatalystActivity:1640163] sphingomyelin phosphodiesterase activity of ENPP7 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1640162] Jassal, B, 2011-10-10
dbId	1640164
displayName	ENPP7 hydrolyzes sphingomyelin
edited	[InstanceEdit:1640162] Jassal, B, 2011-10-10
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Homo sapiens [Reaction:R-HSA-1606583] ASAH2 hydrolyzes ceramide (plasma membrane) - Homo sapiens [Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide - Homo sapiens [Reaction:R-HSA-1638845] CERK phosphorylates CERA to form C1P - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-429776] SPHM d18:1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1640166] Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family [LiteratureReference:1640160] Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ENPP7 hydrolyzes sphingomyelin
orthologousEvent	[Reaction:R-MMU-1640164] ENPP7 hydrolyzes sphingomyelin - Mus musculus [Reaction:R-SCE-1640164] ENPP7 hydrolyzes sphingomyelin - Saccharomyces cerevisiae [Reaction:R-SPO-1640164] ENPP7 hydrolyzes sphingomyelin - Schizosaccharomyces pombe [Reaction:R-DDI-1640164] ENPP7 hydrolyzes sphingomyelin - Dictyostelium discoideum [Reaction:R-CEL-1640164] ENPP7 hydrolyzes sphingomyelin - Caenorhabditis elegans [Reaction:R-GGA-1640164] ENPP7 hydrolyzes sphingomyelin - Gallus gallus [Reaction:R-XTR-1640164] ENPP7 hydrolyzes sphingomyelin - Xenopus tropicalis [Reaction:R-DRE-1640164] ENPP7 hydrolyzes sphingomyelin - Danio rerio [Reaction:R-SSC-1640164] ENPP7 hydrolyzes sphingomyelin - Sus scrofa [Reaction:R-BTA-1640164] ENPP7 hydrolyzes sphingomyelin - Bos taurus [Reaction:R-CFA-1640164] ENPP7 hydrolyzes sphingomyelin - Canis familiaris [Reaction:R-RNO-1640164] ENPP7 hydrolyzes sphingomyelin - Rattus norvegicus
output	[SimpleEntity:R-ALL-429807] CERA [plasma membrane] [SimpleEntity:R-ALL-1610735] ChoP [plasma membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31 [InstanceEdit:9851354] D'Eustachio, Peter, 2023-10-24
revised	[InstanceEdit:9842118] D'Eustachio, Peter, 2023-08-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1640164
summation	[Summation:1640161] Membrane-bound ectonucleotide pyrophosphatase/phosphodiester...
updateTrackers	[UpdateTracker:9842302] Update Tracker - [Reaction:1640164] ENPP7 hydrolyzes sphingomyelin - v86:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9842302] Update Tracker - [Reaction:1640164] ENPP7 hydrolyzes sphingomyelin - v86:[addOutput]
(precedingEvent)	[Reaction:R-HSA-6785933] UGT8 transfers Gal from UDP-Gal to CERA [Reaction:R-HSA-1638845] CERK phosphorylates CERA to form C1P [Reaction:R-HSA-1606583] ASAH2 hydrolyzes ceramide (plasma membrane) [Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism

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