Reactome | ENPP7 hydrolyzes sphingomyelin

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ENPP7 hydrolyzes sphingomyelin Show undefined attributes

catalystActivity	[CatalystActivity:10144017] sphingomyelin phosphodiesterase activity of ENPP7 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10144019
displayName	ENPP7 hydrolyzes sphingomyelin
eventOf	[Pathway:R-CFA-9840310] Glycosphingolipid catabolism - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Canis familiaris [Reaction:R-CFA-1606583] ASAH2 hydrolyzes ceramide (plasma membrane) - Canis familiaris [Reaction:R-CFA-429786] SGMS2 transfers phosphocholine onto ceramide - Canis familiaris [Reaction:R-CFA-1638845] CERK phosphorylates CERA to form C1P - Canis familiaris
inferredFrom	[Reaction:R-HSA-1640164] ENPP7 hydrolyzes sphingomyelin - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-429776] SPHM d18:1 [plasma membrane]
isInDisease	false
isInferred	true
name	ENPP7 hydrolyzes sphingomyelin
output	[SimpleEntity:R-ALL-429807] CERA [plasma membrane] [SimpleEntity:R-ALL-1610735] ChoP [plasma membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-CFA-429786] SGMS2 transfers phosphocholine onto ceramide - Canis familiaris
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1640164
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-6785933] UGT8 transfers Gal from UDP-Gal to CERA [Reaction:R-CFA-1638845] CERK phosphorylates CERA to form C1P [Reaction:R-CFA-1606583] ASAH2 hydrolyzes ceramide (plasma membrane) [Reaction:R-CFA-429786] SGMS2 transfers phosphocholine onto ceramide
(hasEvent)	[Pathway:R-CFA-9840310] Glycosphingolipid catabolism
(inferredTo)	[Reaction:R-HSA-1640164] ENPP7 hydrolyzes sphingomyelin