Reactome | UGT8 transfers Gal from UDP-Gal to CERA

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UGT8 transfers Gal from UDP-Gal to CERA Show undefined attributes

authored	[InstanceEdit:6785919] Jassal, Bijay, 2015-07-02
catalystActivity	[CatalystActivity:6785918] N-acylsphingosine galactosyltransferase activity of UGT8 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6785919] Jassal, Bijay, 2015-07-02
crossReference	[DatabaseIdentifier:12667872] RHEA:48344
dbId	6785933
displayName	UGT8 transfers Gal from UDP-Gal to CERA
edited	[InstanceEdit:6785919] Jassal, Bijay, 2015-07-02
eventOf	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9844955] CLN3 transports GalCer to plasma membrane - Homo sapiens [Reaction:R-HSA-9844587] GAL3ST1 transfers sulfate to GalCer,LacCer - Homo sapiens [Reaction:R-HSA-9844860] ST3GAL5 transfers NeuNAc to ceramides - Homo sapiens [BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-428256] CERA [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1981137] UDP-Gal [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6785913] Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA [LiteratureReference:6785916] Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance [LiteratureReference:9844573] UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	UGT8 transfers Gal from UDP-Gal to CERA
orthologousEvent	[Reaction:R-CEL-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Caenorhabditis elegans [Reaction:R-DME-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Drosophila melanogaster [Reaction:R-GGA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Gallus gallus [Reaction:R-DRE-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Danio rerio [Reaction:R-SSC-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Sus scrofa [Reaction:R-BTA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Bos taurus [Reaction:R-CFA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Canis familiaris [Reaction:R-RNO-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Rattus norvegicus [Reaction:R-MMU-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Mus musculus
output	[SimpleEntity:R-ALL-6785915] GalCer [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-158602] UDP [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-1640164] ENPP7 hydrolyzes sphingomyelin - Homo sapiens [Reaction:R-HSA-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Homo sapiens [Reaction:R-HSA-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797578] D'Eustachio, Peter, 2015-09-14 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6785933
summation	[Summation:6785921] 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8,...
updateTrackers	[UpdateTracker:9853185] Update Tracker - [Reaction:6785933] UGT8 transfers Gal from UDP-Gal to CERA - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853185] Update Tracker - [Reaction:6785933] UGT8 transfers Gal from UDP-Gal to CERA - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane [BlackBoxEvent:R-HSA-9844955] CLN3 transports GalCer to plasma membrane [Reaction:R-HSA-9844587] GAL3ST1 transfers sulfate to GalCer,LacCer [Reaction:R-HSA-9844860] ST3GAL5 transfers NeuNAc to ceramides
(hasEvent)	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis

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