Reactome | CERK phosphorylates CERA to form C1P

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CERK phosphorylates CERA to form C1P Show undefined attributes

authored	[InstanceEdit:1638838] Jassal, Bijay, 2011-10-10
catalystActivity	[CatalystActivity:1638839] ceramide kinase activity of CERK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1638838] Jassal, Bijay, 2011-10-10
dbId	1638845
displayName	CERK phosphorylates CERA to form C1P
edited	[InstanceEdit:1638838] Jassal, Bijay, 2011-10-10
eventOf	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-5339535] CPTP transports C1P from plasma membrane to Golgi membrane - Homo sapiens [BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-429807] CERA [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1638837] Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization [LiteratureReference:9845267] Ceramide kinase: the first decade [LiteratureReference:9845268] The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CERK phosphorylates CERA to form C1P Ceramide kinase (CERK) mediates the phosphorylation of ceramide
orthologousEvent	[Reaction:R-CEL-1638845] CERK phosphorylates CERA to form C1P - Caenorhabditis elegans [Reaction:R-DME-1638845] CERK phosphorylates CERA to form C1P - Drosophila melanogaster [Reaction:R-GGA-1638845] CERK phosphorylates CERA to form C1P - Gallus gallus [Reaction:R-XTR-1638845] CERK phosphorylates CERA to form C1P - Xenopus tropicalis [Reaction:R-DRE-1638845] CERK phosphorylates CERA to form C1P - Danio rerio [Reaction:R-SSC-1638845] CERK phosphorylates CERA to form C1P - Sus scrofa [Reaction:R-BTA-1638845] CERK phosphorylates CERA to form C1P - Bos taurus [Reaction:R-CFA-1638845] CERK phosphorylates CERA to form C1P - Canis familiaris [Reaction:R-RNO-1638845] CERK phosphorylates CERA to form C1P - Rattus norvegicus [Reaction:R-MMU-1638845] CERK phosphorylates CERA to form C1P - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1638840] C1P [plasma membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Homo sapiens [Reaction:R-HSA-1640164] ENPP7 hydrolyzes sphingomyelin - Homo sapiens [Reaction:R-HSA-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1638845
summation	[Summation:1638836] Ceramide kinase (CERK) mediates the phosphorylation of ceram...
updateTrackers	[UpdateTracker:9853264] Update Tracker - [Reaction:1638845] CERK phosphorylates CERA to form C1P - v87:[addLiteratureReference, addOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853264] Update Tracker - [Reaction:1638845] CERK phosphorylates CERA to form C1P - v87:[addLiteratureReference, addOutput, modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-9850731] Vesicles transport GSL from Golgi to plasma membrane [Reaction:R-HSA-5339535] CPTP transports C1P from plasma membrane to Golgi membrane
(hasEvent)	[Pathway:R-HSA-9840309] Glycosphingolipid biosynthesis