Reactome | ENPP7 hydrolyzes sphingomyelin

ENPP7 hydrolyzes sphingomyelin

Stable Identifier

R-HSA-1640164

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Membrane-bound ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) mediates the hydrolysis of sphingomyelin to ceramide and choline phosphate (Duan et al. 2003, Wu et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
12885774	Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family Nelander, S, Cheng, Y, Bergman, T, Duan, RD, Xu, N, Palmberg, C, Duan, J, Wu, J, Nilsson, A	J Biol Chem	2003
15458386	Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis Hansen, GH, Duan, RD, Wu, J, Nilsson, A	Biochem J	2005