Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin

Stable Identifier
R-HSA-1640164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin
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Membrane-bound ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) mediates the hydrolysis of sphingomyelin to ceramide and choline phosphate (Duan et al. 2003, Wu et al. 2005).

Literature References
PubMed ID Title Journal Year
12885774 Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family

Nelander, S, Cheng, Y, Bergman, T, Duan, RD, Xu, N, Palmberg, C, Duan, J, Wu, J, Nilsson, A

J Biol Chem 2003
15458386 Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis

Hansen, GH, Duan, RD, Wu, J, Nilsson, A

Biochem J 2005
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Catalyst Activity

sphingomyelin phosphodiesterase activity of ENPP7 [plasma membrane]

Physical Entity
ENPP7 [plasma membrane] (Homo sapiens)
Activity
sphingomyelin phosphodiesterase activity (GO:0004767)
Orthologous Events
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Bos taurus)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Canis familiaris)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Danio rerio)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Dictyostelium discoideum)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Gallus gallus)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Mus musculus)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Rattus norvegicus)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Saccharomyces cerevisiae)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Schizosaccharomyces pombe)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Sus scrofa)
Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-10)
Reviewed
Stephan, R  (2011-10-31)
Created
Jassal, B  (2011-10-10)
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