G alpha (s) activates adenylate cyclase

Stable Identifier
R-HSA-163617
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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G alpha (s) activates adenylate cyclase
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G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.
Literature References
PubMed ID Title Journal Year
12058044 Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase

Dessauer, CW, Chen-Goodspeed, M, Chen, J

J. Biol. Chem. 2002
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Tesmer, JJ, Sunahara, RK, Gilman, AG, Sprang, SR

Science 1997
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Output
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Catalyst Activity

adenylate cyclase activator activity of G alpha (s):GTP [plasma membrane]

Physical Entity
G alpha (s):GTP [plasma membrane] (Homo sapiens)
Activity
adenylate cyclase activator activity (GO:0010856)
Orthologous Events
GNAL:GTP (G alpha-olf) binds ADCY3 (Homo sapiens)
Authored
Jupe, S  (2009-03-09)
Reviewed
Akkerman, JW  (2009-06-03)
D'Eustachio, P  (2024-01-29)
D'Eustachio, P  (2024-01-29)
Created
Gopinathrao, G  (2005-05-04)
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