Reactome | TPMT does not transfer CH3 from AdoMet to 6MP

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TPMT does not transfer CH3 from AdoMet to 6MP Show undefined attributes

authored	[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01
catalystActivity	[CatalystActivity:9631841] thiopurine S-methyltransferase activity of TPMT mutants [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01
crossReference	[DatabaseIdentifier:12020859] Mondo:0019052
dbId	5603379
disease	[Disease:5602847] inherited metabolic disorder
displayName	TPMT does not transfer CH3 from AdoMet to 6MP
edited	[InstanceEdit:5603368] Jassal, Bijay, 2014-07-01
entityFunctionalStatus	[EntityFunctionalStatus:5603347] loss_of_function of TPMT mutants [cytosol]
eventOf	[Pathway:R-HSA-5578995] Defective TPMT causes TPMT deficiency - Homo sapiens
input	[SimpleEntity:R-ALL-158619] 6MP [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5603364] Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism [LiteratureReference:5603340] Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT3A and identification of a novel sequence variant, TPMT23 [LiteratureReference:5603350] Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT3A, TPMT2): mechanisms for the genetic polymorphism of TPMT activity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TPMT does not transfer CH3 from AdoMet to 6MP
normalReaction	[Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5634119] Nakaki, Toshio, 2014-11-03
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5603379
summation	[Summation:5603355] 6-mercaptopurine (6MP) is used in the treatment of inflammat...
systematicName	TPMT mutants do not transfer CH3 from AdoMet to 6MP
updateTrackers	[UpdateTracker:9778253] Update Tracker - [FailedReaction:5603379] TPMT does not transfer CH3 from AdoMet to 6MP - v68:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9778253] Update Tracker - [FailedReaction:5603379] TPMT does not transfer CH3 from AdoMet to 6MP - v68:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-5578995] Defective TPMT causes TPMT deficiency

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