Reactome | PA is dephosphorylated to DAG by LPIN

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PA is dephosphorylated to DAG by LPIN Show undefined attributes

catalystActivity	[CatalystActivity:11062903] phosphatidate phosphatase activity of LPIN [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11062905
displayName	PA is dephosphorylated to DAG by LPIN
eventOf	[Pathway:R-SPO-1483213] Synthesis of PE - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Schizosaccharomyces pombe [Reaction:R-SPO-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-1483203] PA is dephosphorylated to DAG by LPIN - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PA is dephosphorylated to DAG by LPIN
output	[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SPO-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Schizosaccharomyces pombe [Reaction:R-SPO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-1483203
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-1483213] Synthesis of PE [Pathway:R-SPO-1483191] Synthesis of PC
(precedingEvent)	[Reaction:R-SPO-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 [Reaction:R-SPO-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
(inferredTo)	[Reaction:R-HSA-1483203] PA is dephosphorylated to DAG by LPIN