Reactome | PE is hydrolyzed to 1-acyl LPE by PLA2[3]

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PE is hydrolyzed to 1-acyl LPE by PLA2[3] Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524133] A2-type glycerophospholipase activity of PLA2(3) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482887
displayName	PE is hydrolyzed to 1-acyl LPE by PLA2[3]
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482839] Acyl chain remodelling of PE - Homo sapiens
followingEvent	[Reaction:R-HSA-1482571] 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C - Homo sapiens [Reaction:R-HSA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1500581] PE [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482931] Structure and properties of a human non-pancreatic phospholipase A2 [LiteratureReference:1482657] Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 [LiteratureReference:1482805] Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PE is hydrolyzed to 1-acyl LPE by PLA2[3]
orthologousEvent	[Reaction:R-MMU-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Mus musculus [Reaction:R-DDI-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Dictyostelium discoideum [Reaction:R-CEL-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Caenorhabditis elegans [Reaction:R-GGA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Gallus gallus [Reaction:R-XTR-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Xenopus tropicalis [Reaction:R-SSC-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Sus scrofa [Reaction:R-BTA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Bos taurus [Reaction:R-CFA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Canis familiaris [Reaction:R-RNO-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Rattus norvegicus
output	[SimpleEntity:R-ALL-1498738] 1-acyl LPE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1483077] PE transports from the mitochondrial membrane to the ER - Homo sapiens [Reaction:R-HSA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Homo sapiens [Reaction:R-HSA-1482646] 2-acyl LPE is acylated to PE by LPEAT - Homo sapiens [Reaction:R-HSA-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482887
summation	[Summation:1482812] At the endoplasmic reticulum (ER) membrane, phosphatidyletha...

Referrals

(hasEvent)	[Pathway:R-HSA-1482839] Acyl chain remodelling of PE
(precedingEvent)	[Reaction:R-HSA-1482571] 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C [Reaction:R-HSA-1482667] 1-acyl LPE is acylated to PE by LPEAT

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