Reactome | 1-acyl LPE is acylated to PE by LPEAT

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1-acyl LPE is acylated to PE by LPEAT Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524039] 1-acylglycerol-3-phosphate O-acyltransferase activity of LPEAT [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
dbId	1482667
displayName	1-acyl LPE is acylated to PE by LPEAT
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482839] Acyl chain remodelling of PE - Homo sapiens
followingEvent	[Reaction:R-HSA-1482884] PE is hydrolyzed to 1-acyl LPE by PLA2[2] - Homo sapiens [Reaction:R-HSA-1483174] PE is methylated to PC by PEMT - Homo sapiens [Reaction:R-HSA-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] - Homo sapiens [Reaction:R-HSA-1482892] PE is hydrolyzed to 2-acyl LPE by PLA2G4C - Homo sapiens [Reaction:R-HSA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Homo sapiens [Reaction:R-HSA-1483089] PE is converted to PS by PTDSS2 - Homo sapiens
input	[SimpleEntity:R-ALL-1498738] 1-acyl LPE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482645] Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity [LiteratureReference:429002] Identification and characterization of a major liver lysophosphatidylcholine acyltransferase [LiteratureReference:1482630] Characterization of human lysophospholipid acyltransferase 3 [LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils [LiteratureReference:1482687] Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 [LiteratureReference:1482536] Substrate preferences of a lysophosphatidylcholine acyltransferase highlight its role in phospholipid remodeling
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	1-acyl LPE is acylated to PE by LPEAT
orthologousEvent	[Reaction:R-PFA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Plasmodium falciparum [Reaction:R-MMU-1482667] 1-acyl LPE is acylated to PE by LPEAT - Mus musculus [Reaction:R-SCE-1482667] 1-acyl LPE is acylated to PE by LPEAT - Saccharomyces cerevisiae [Reaction:R-SPO-1482667] 1-acyl LPE is acylated to PE by LPEAT - Schizosaccharomyces pombe [Reaction:R-DDI-1482667] 1-acyl LPE is acylated to PE by LPEAT - Dictyostelium discoideum [Reaction:R-CEL-1482667] 1-acyl LPE is acylated to PE by LPEAT - Caenorhabditis elegans [Reaction:R-DME-1482667] 1-acyl LPE is acylated to PE by LPEAT - Drosophila melanogaster [Reaction:R-GGA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Gallus gallus [Reaction:R-XTR-1482667] 1-acyl LPE is acylated to PE by LPEAT - Xenopus tropicalis [Reaction:R-DRE-1482667] 1-acyl LPE is acylated to PE by LPEAT - Danio rerio [Reaction:R-SSC-1482667] 1-acyl LPE is acylated to PE by LPEAT - Sus scrofa [Reaction:R-BTA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Bos taurus [Reaction:R-CFA-1482667] 1-acyl LPE is acylated to PE by LPEAT - Canis familiaris [Reaction:R-RNO-1482667] 1-acyl LPE is acylated to PE by LPEAT - Rattus norvegicus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-1500581] PE [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1482884] PE is hydrolyzed to 1-acyl LPE by PLA2[2] - Homo sapiens [Reaction:R-HSA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3] - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482667
summation	[Summation:1482538] At the endoplasmic reticulum (ER) membrane, lysophospholipid...

Referrals

(precedingEvent)	[Reaction:R-HSA-1483174] PE is methylated to PC by PEMT [Reaction:R-HSA-1482828] PE is hydrolyzed to 2-acyl LPE by PLA2[4] [Reaction:R-HSA-1482892] PE is hydrolyzed to 2-acyl LPE by PLA2G4C [Reaction:R-HSA-1483089] PE is converted to PS by PTDSS2 [Reaction:R-HSA-1482884] PE is hydrolyzed to 1-acyl LPE by PLA2[2] [Reaction:R-HSA-1482887] PE is hydrolyzed to 1-acyl LPE by PLA2[3]
(hasEvent)	[Pathway:R-HSA-1482839] Acyl chain remodelling of PE

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