PE is hydrolyzed to 1-acyl LPE by PLA2[3]

Stable Identifier
R-HSA-1482887
Type
Reaction
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
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PE is hydrolyzed to 1-acyl LPE by PLA2[3]
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At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, (PLA2G2A) or by calcium-independent phospholipase A2-gamma (PNPLA8), to form 1-acyl lysophosphatidylethanolamine (LPE) (Murakami et al. 2005, Kramer et al. 1989, Singer et al. 2002).

Literature References
PubMed ID Title Journal Year
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E

J Biol Chem 2002
2925633 Structure and properties of a human non-pancreatic phospholipase A2

Chow, EP, Hayes, G, Johansen, B, Tizard, R, Kramer, RM, McGray, P, Pepinsky, RB, Hession, C

J Biol Chem 1989
15695510 Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2

Takanezawa, Y, Ishikawa, Y, Kuwata, H, Masuda, S, Kudo, I, Ishii, T, Aoki, J, Arai, H, Sumimoto, H, Murakami, M, Ueda-Semmyo, K, Nakatani, Y, Yoda, E

J Biol Chem 2005
Participants
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Output
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as an event of
Catalyst Activity

phospholipase A2 activity of PLA2(3) [endoplasmic reticulum membrane]

Physical Entity
PLA2(3) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phospholipase A2 activity (GO:0004623)
Orthologous Events
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Danio rerio)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Gallus gallus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Plasmodium falciparum)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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