PE is hydrolyzed to 1-acyl LPE by PLA2[3]

Stable Identifier
R-HSA-1482887
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PE is hydrolyzed to 1-acyl LPE by PLA2[3]
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, (PLA2G2A) or by calcium-independent phospholipase A2-gamma (PNPLA8), to form 1-acyl lysophosphatidylethanolamine (LPE) (Murakami et al. 2005, Kramer et al. 1989, Singer et al. 2002).

Literature References
PubMed ID Title Journal Year
2925633 Structure and properties of a human non-pancreatic phospholipase A2

Kramer, RM, Hession, C, Johansen, B, Hayes, G, McGray, P, Chow, EP, Tizard, R, Pepinsky, RB

J Biol Chem 1989
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH

J Biol Chem 2002
15695510 Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2

Murakami, M, Masuda, S, Ueda-Semmyo, K, Yoda, E, Kuwata, H, Takanezawa, Y, Aoki, J, Arai, H, Sumimoto, H, Ishikawa, Y, Ishii, T, Nakatani, Y, Kudo, I

J Biol Chem 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phospholipase A2 activity of PLA2(3) [endoplasmic reticulum membrane]
Physical Entity
PLA2(3) [endoplasmic reticulum membrane]
Activity
phospholipase A2 activity (0004623)
Orthologous Events
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Danio rerio)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Gallus gallus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Plasmodium falciparum)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
Cite Us!