PE is hydrolyzed to 1-acyl LPE by PLA2[3]

Stable Identifier
Reaction [transition]
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, (PLA2G2A) or by calcium-independent phospholipase A2-gamma (PNPLA8), to form 1-acyl lysophosphatidylethanolamine (LPE) (Murakami et al. 2005, Kramer et al. 1989, Singer et al. 2002).

Literature References
PubMed ID Title Journal Year
2925633 Structure and properties of a human non-pancreatic phospholipase A2

Kramer, RM, Hession, C, Johansen, B, Hayes, G, McGray, P, Chow, EP, Tizard, R, Pepinsky, RB

J Biol Chem 1989
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH

J Biol Chem 2002
15695510 Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2

Murakami, M, Masuda, S, Ueda-Semmyo, K, Yoda, E, Kuwata, H, Takanezawa, Y, Aoki, J, Arai, H, Sumimoto, H, Ishikawa, Y, Ishii, T, Nakatani, Y, Kudo, I

J Biol Chem 2005
Participant Of
Catalyst Activity
Catalyst Activity
phospholipase A2 activity of PLA2(3) [endoplasmic reticulum membrane]
Physical Entity
Orthologous Events
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