Reactome | DAG is acylated to TAG by DGAT1/2

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DAG is acylated to TAG by DGAT1/2 Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1500598] diacylglycerol O-acyltransferase activity of DGAT1/2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482889
displayName	DAG is acylated to TAG by DGAT1/2
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG - Homo sapiens
followingEvent	[Reaction:R-HSA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Homo sapiens
input	[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol] [SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482898] Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes [LiteratureReference:549174] Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members [LiteratureReference:549189] A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DAG is acylated to TAG by DGAT1/2
orthologousEvent	[Reaction:R-MMU-1482889] DAG is acylated to TAG by DGAT1/2 - Mus musculus [Reaction:R-SCE-1482889] DAG is acylated to TAG by DGAT1/2 - Saccharomyces cerevisiae [Reaction:R-SPO-1482889] DAG is acylated to TAG by DGAT1/2 - Schizosaccharomyces pombe [Reaction:R-DDI-1482889] DAG is acylated to TAG by DGAT1/2 - Dictyostelium discoideum [Reaction:R-PFA-1482889] DAG is acylated to TAG by DGAT1/2 - Plasmodium falciparum [Reaction:R-CEL-1482889] DAG is acylated to TAG by DGAT1/2 - Caenorhabditis elegans [Reaction:R-DME-1482889] DAG is acylated to TAG by DGAT1/2 - Drosophila melanogaster [Reaction:R-GGA-1482889] DAG is acylated to TAG by DGAT1/2 - Gallus gallus [Reaction:R-XTR-1482889] DAG is acylated to TAG by DGAT1/2 - Xenopus tropicalis [Reaction:R-DRE-1482889] DAG is acylated to TAG by DGAT1/2 - Danio rerio [Reaction:R-SSC-1482889] DAG is acylated to TAG by DGAT1/2 - Sus scrofa [Reaction:R-BTA-1482889] DAG is acylated to TAG by DGAT1/2 - Bos taurus [Reaction:R-CFA-1482889] DAG is acylated to TAG by DGAT1/2 - Canis familiaris [Reaction:R-RNO-1482889] DAG is acylated to TAG by DGAT1/2 - Rattus norvegicus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-1500594] TAG [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Homo sapiens [Reaction:R-HSA-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 - Homo sapiens [Reaction:R-HSA-5696448] AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482889
summation	[Summation:1482908] At the endoplasmic reticulum (ER) membrane, diacylglycerol (...

Referrals

(hasEvent)	[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG
(precedingEvent)	[Reaction:R-HSA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3

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