TAG is hydrolyzed to DAG by PNPLA2/3

Stable Identifier
R-HSA-1482777
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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TAG is hydrolyzed to DAG by PNPLA2/3
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At the endoplasmic reticulum (ER) membrane, triacylglycerol (TAG) is hydrolyzed, removing one of its acyl groups to form diacylglycerol (DAG) by patatin-like phospholipase domain-containing protein 2/3 (PNPLA2/3) (He et al. 2010, Jenkins et al. 2004, Basantani et al. 2011).

Literature References
PubMed ID Title Journal Year
21068004 Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

Kershaw, EE, Schoiswohl, G, Gardner, NP, Yang, K, Basantani, MK, Sitnick, MT, Gross, RW, Li, JZ, Brenner, DS, Zechner, R, Cai, L, Kumari, M

J Lipid Res 2011
20034933 A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

Garuti, R, Hobbs, HH, Kinch, L, McPhaul, C, Cohen, JC, Li, JZ, Grishin, NV, He, S

J Biol Chem 2010
15364929 Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities

Gibson, B, Yan, W, Sims, HF, Gross, RW, Jenkins, CM, Mancuso, DJ

J Biol Chem 2004
Participants
Input
Output
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as an event of
Catalyst Activity

triglyceride lipase activity of PNPLA2/3 [endoplasmic reticulum membrane]

Physical Entity
PNPLA2/3 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
triglyceride lipase activity (GO:0004806)
Orthologous Events
TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)
TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)
TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)
TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)
TAG is hydrolyzed to DAG by PNPLA2/3 (Gallus gallus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)
TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)
TAG is hydrolyzed to DAG by PNPLA2/3 (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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