Reactome | DAG is hydrolyzed to 2-MAG by PNPLA2/3

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DAG is hydrolyzed to 2-MAG by PNPLA2/3 Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1500597] lipoprotein lipase activity of PNPLA2/3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482811
displayName	DAG is hydrolyzed to 2-MAG by PNPLA2/3
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG - Homo sapiens
followingEvent	[Reaction:R-HSA-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL - Homo sapiens [Reaction:R-HSA-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 - Homo sapiens [Reaction:R-HSA-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 - Homo sapiens
input	[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482692] Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities [LiteratureReference:1482706] A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis [LiteratureReference:1482888] Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DAG is hydrolyzed to 2-MAG by PNPLA2/3
orthologousEvent	[Reaction:R-MMU-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Mus musculus [Reaction:R-PFA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Plasmodium falciparum [Reaction:R-CEL-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Caenorhabditis elegans [Reaction:R-DME-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Drosophila melanogaster [Reaction:R-GGA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Gallus gallus [Reaction:R-XTR-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Xenopus tropicalis [Reaction:R-DRE-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Danio rerio [Reaction:R-SSC-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Sus scrofa [Reaction:R-BTA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Bos taurus [Reaction:R-CFA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Canis familiaris [Reaction:R-RNO-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Rattus norvegicus
output	[SimpleEntity:R-ALL-1498728] 2-MAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 - Homo sapiens [Reaction:R-HSA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Homo sapiens [Reaction:R-HSA-5696448] AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482811
summation	[Summation:1482902] At the endoplasmic reticulum (ER) membrane, patatin-like pho...

Referrals

(hasEvent)	[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG
(precedingEvent)	[Reaction:R-HSA-1482543] 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL [Reaction:R-HSA-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 [Reaction:R-HSA-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3

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