Reactome | TAG is hydrolyzed to DAG by PNPLA2/3

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TAG is hydrolyzed to DAG by PNPLA2/3 Show undefined attributes

catalystActivity	[CatalystActivity:10033369] triacylglycerol lipase activity of PNPLA2/3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10033371
displayName	TAG is hydrolyzed to DAG by PNPLA2/3
eventOf	[Pathway:R-MMU-1482883] Acyl chain remodeling of DAG and TAG - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Mus musculus [Reaction:R-MMU-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 - Mus musculus [Reaction:R-MMU-1482889] DAG is acylated to TAG by DGAT1/2 - Mus musculus [Reaction:R-MMU-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Mus musculus [Reaction:R-MMU-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1500594] TAG [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TAG is hydrolyzed to DAG by PNPLA2/3
output	[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-MMU-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 - Mus musculus [Reaction:R-MMU-1482889] DAG is acylated to TAG by DGAT1/2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1482777
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1482883] Acyl chain remodeling of DAG and TAG
(precedingEvent)	[Reaction:R-MMU-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 [Reaction:R-MMU-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Reaction:R-MMU-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 [Reaction:R-MMU-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 [Reaction:R-MMU-1482889] DAG is acylated to TAG by DGAT1/2
(inferredTo)	[Reaction:R-HSA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3