Activation of RAS by p-KIT bound SOS1

Stable Identifier
R-HSA-1433471
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Activation of RAS by p-KIT bound SOS1
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Once recruited to the membrane in response to c-Kit stimulation, Son of sevenless (SOS1) activates the small GTPase protein RAS. SOS1 is a dual specificity guanine nucleotide exchange factor (GEF) that regulates both Ras and Rho family GTPases. SOS1 activates RAS by binding, which induces a conformational change that causes the exchange of GDP for GTP. RAS proteins are membrane-bound GTPases that regulate crucial cellular processes such as growth, proliferation and differentiation. Active RAS-GTP stimulates multiple effector proteins such as RAF-1, which induce a variety of cellular responses including initiation of mitogen activated protein kinase (MAPK) cascade signaling.

Literature References
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-KIT complex [plasma membrane]
Physical Entity
GRB2:SOS1:p-KIT complex [plasma membrane]
Activity
Ras guanyl-nucleotide exchange factor activity (0005088)
Orthologous Events
Activation of RAS by p-KIT bound SOS1 (Bos taurus)
Activation of RAS by p-KIT bound SOS1 (Canis familiaris)
Activation of RAS by p-KIT bound SOS1 (Danio rerio)
Activation of RAS by p-KIT bound SOS1 (Drosophila melanogaster)
Activation of RAS by p-KIT bound SOS1 (Gallus gallus)
Activation of RAS by p-KIT bound SOS1 (Mus musculus)
Activation of RAS by p-KIT bound SOS1 (Rattus norvegicus)
Activation of RAS by p-KIT bound SOS1 (Sus scrofa)
Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-07-11)
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