Reactome | Activation of RAS by p-KIT bound SOS1

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Activation of RAS by p-KIT bound SOS1 Show undefined attributes

catalystActivity	[CatalystActivity:10771152] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-KIT complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10771154
displayName	Activation of RAS by p-KIT bound SOS1
eventOf	[Pathway:R-GGA-1433557] Signaling by SCF-KIT - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-GGA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of RAS by p-KIT bound SOS1
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-GGA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-GGA-205286] GRB2:SOS interacts with p-KIT - Gallus gallus [Reaction:R-GGA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1433471
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1433557] Signaling by SCF-KIT
(inferredTo)	[Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1

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