Reactome | BCL2 binds BCL2 antagonists

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BCL2 binds BCL2 antagonists Show undefined attributes

authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
category	binding
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:9692328] Jassal, Bijay, 2020-06-22
dbId	9692376
definition	Antagonist
displayName	BCL2 binds BCL2 antagonists
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-50757] BCL2 [mitochondrial outer membrane] [CandidateSet:R-ALL-9692432] BCL2 antagonists [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9692425] ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets [LiteratureReference:9692358] ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor [LiteratureReference:9692331] Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL [LiteratureReference:9692356] A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells [LiteratureReference:9692413] The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies [LiteratureReference:9692388] Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	BCL2 binds BCL2 antagonists
orthologousEvent	[Reaction:R-CEL-9692376] BCL2 binds BCL2 antagonists - Caenorhabditis elegans [Reaction:R-GGA-9692376] BCL2 binds BCL2 antagonists - Gallus gallus [Reaction:R-XTR-9692376] BCL2 binds BCL2 antagonists - Xenopus tropicalis [Reaction:R-DRE-9692376] BCL2 binds BCL2 antagonists - Danio rerio [Reaction:R-SSC-9692376] BCL2 binds BCL2 antagonists - Sus scrofa [Reaction:R-BTA-9692376] BCL2 binds BCL2 antagonists - Bos taurus [Reaction:R-CFA-9692376] BCL2 binds BCL2 antagonists - Canis familiaris [Reaction:R-MMU-9692376] BCL2 binds BCL2 antagonists - Mus musculus
output	[Complex:R-HSA-9692353] BCL2:BCL2 antagonists [mitochondrial outer membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9692376
summation	[Summation:9692397] Apoptosis is governed by two pathways that ultimately lead t...

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(hasEvent)

[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

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