Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Schema > Pathway > Entries

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Show undefined attributes

compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10728900
displayName	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
eventOf	[Pathway:R-XTR-109606] Intrinsic Pathway for Apoptosis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133703] positive regulation of intrinsic apoptotic signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-9692376] BCL2 binds BCL2 antagonists - Xenopus tropicalis [Reaction:R-XTR-114352] Sequestration of tBID by BCL-2 - Xenopus tropicalis [Reaction:R-XTR-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-111453
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-109606] Intrinsic Pathway for Apoptosis
(inferredTo)	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Cite Us!