BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Stable Identifier
R-HSA-111453
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
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Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath et al. 1999), PUMA (Nakano and Vousden 2001), NOXA (Oda et al. 2000), BAD (Yang et al. 2005), BMF (Puthalakath et al. 2001), resulting in inactivation of BCL2. Binding of BCL2 to tBID inhibits BID-induced cytochrome C release and apoptosis (Yi et al. 2003). BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL.
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
positive regulation of intrinsic apoptotic signaling pathway (2001244)
Orthologous Events
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Bos taurus)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Caenorhabditis elegans)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Canis familiaris)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Danio rerio)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Gallus gallus)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Mus musculus)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Rattus norvegicus)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Sus scrofa)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Xenopus tropicalis)
Cross References
BioModels Database
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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