Reactome | Expression of BCL2, BCL2L1

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Expression of BCL2, BCL2L1 Show undefined attributes

authored	[InstanceEdit:6785864] Jupe, Steve, 2015-07-01
category	omitted
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:6790027] Jupe, Steve, 2015-08-06
dbId	6790025
displayName	Expression of BCL2, BCL2L1
edited	[InstanceEdit:8937485] Jupe, Steve, 2016-09-02
eventOf	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Homo sapiens [Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling - Homo sapiens
input	[DefinedSet:R-HSA-6790035] BCL2 gene, BCL2L1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6789622] STAT3 Target Genes Relevant to Human Cancers [LiteratureReference:6793963] STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells [LiteratureReference:6789552] Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of BCL2, BCL2L1
output	[DefinedSet:R-HSA-879209] Bcl-2/Bcl-X(L) [mitochondrial outer membrane]
precedingEvent	[BlackBoxEvent:R-HSA-6786293] p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-6797263] Positive gene expression regulation by 'p-Y705-STAT3 dimer [nucleoplasm]'
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8937491] Leibovich, Samuel, 2016-09-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6790025
summation	[Summation:6793972] Signal transducer and activator of transcription 3 (STAT3) i...
updateTrackers	[UpdateTracker:9775585] Update Tracker - [BlackBoxEvent:6790025] Expression of BCL2, BCL2L1 - v78:[modifyText] [UpdateTracker:9776361] Update Tracker - [BlackBoxEvent:6790025] Expression of BCL2, BCL2L1 - v76:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775585] Update Tracker - [BlackBoxEvent:6790025] Expression of BCL2, BCL2L1 - v78:[modifyText] [UpdateTracker:9776361] Update Tracker - [BlackBoxEvent:6790025] Expression of BCL2, BCL2L1 - v76:[modifyText]
(hasEvent)	[Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling [Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members