Reactome | HERC2 and PIAS4 are recruited to DNA DSBs

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HERC2 and PIAS4 are recruited to DNA DSBs Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10794327
displayName	HERC2 and PIAS4 are recruited to DNA DSBs
eventOf	[Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-5682598] ATM phosphorylates HERC2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-5682586] HERC2 and PIAS4 are recruited to DNA DSBs - Homo sapiens
input	[Complex:R-GGA-5682585] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-4551680] HERC2 [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-2993789] PIAS4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	HERC2 and PIAS4 are recruited to DNA DSBs
output	[Complex:R-GGA-5682590] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-5682588] RNF8 binds phosphorylated MDC1 at DNA DSBs - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5682586
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-GGA-5682598] ATM phosphorylates HERC2
(inferredTo)	[Reaction:R-HSA-5682586] HERC2 and PIAS4 are recruited to DNA DSBs