Reactome | BAP1 binds BRCA1:BARD1 heterodimer

Schema > Reaction > Entries

BAP1 binds BRCA1:BARD1 heterodimer Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10818010
displayName	BAP1 binds BRCA1:BARD1 heterodimer
eventOf	[Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-9700998] BAP1 disrupts the BRCA1:BARD1 heterodimer - Gallus gallus
inferredFrom	[Reaction:R-HSA-9701003] BAP1 binds BRCA1:BARD1 heterodimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-5689665] BAP1 [nucleoplasm] [Complex:R-GGA-5659802] BRCA1:BARD1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	BAP1 binds BRCA1:BARD1 heterodimer
output	[Complex:R-GGA-9701007] BRCA1:BARD1:BAP1 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-5659781] BRCA1 forms a heterodimer with BARD1 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-9701003
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-GGA-9700998] BAP1 disrupts the BRCA1:BARD1 heterodimer
(inferredTo)	[Reaction:R-HSA-9701003] BAP1 binds BRCA1:BARD1 heterodimer

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