Reactome | p-T68-CHEK2 autophosphorylates

Schema > Reaction > Entries

p-T68-CHEK2 autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10794472] protein serine/threonine kinase activity of p-T68-CHEK2 dimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10794474
displayName	p-T68-CHEK2 autophosphorylates
eventOf	[Pathway:R-GGA-69473] G2/M DNA damage checkpoint - Gallus gallus [Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-5683801] CHEK2 phosphorylates BRCA1 - Gallus gallus [Reaction:R-GGA-349426] Phosphorylation of MDM4 by CHEK2 - Gallus gallus [Reaction:R-GGA-69608] Phosphorylation of CDC25A by CHEK2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-5683792] p-T68-CHEK2 autophosphorylates - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-5683773] p-T68-CHEK2 dimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	p-T68-CHEK2 autophosphorylates
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-GGA-5683784] phospho-CHEK2 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-5683774] p-T68-CHEK2 dimerizes - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5683792
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Pathway:R-GGA-69473] G2/M DNA damage checkpoint
(precedingEvent)	[Reaction:R-GGA-349426] Phosphorylation of MDM4 by CHEK2 [Reaction:R-GGA-69608] Phosphorylation of CDC25A by CHEK2 [Reaction:R-GGA-5683801] CHEK2 phosphorylates BRCA1
(inferredTo)	[Reaction:R-HSA-5683792] p-T68-CHEK2 autophosphorylates