Reactome | Phosphorylation and activation of CHEK2 by ATM

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Phosphorylation and activation of CHEK2 by ATM Show undefined attributes

catalystActivity	[CatalystActivity:10733429] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10733431
displayName	Phosphorylation and activation of CHEK2 by ATM
eventOf	[Pathway:R-GGA-69473] G2/M DNA damage checkpoint - Gallus gallus [Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-69608] Phosphorylation of CDC25A by CHEK2 - Gallus gallus [Reaction:R-GGA-5683774] p-T68-CHEK2 dimerizes - Gallus gallus
inferredFrom	[Reaction:R-HSA-69891] Phosphorylation and activation of CHEK2 by ATM - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-5683737] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation and activation of CHEK2 by ATM
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-GGA-5683605] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-113825] phospho-CHEK2 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-5683735] CHEK2 is recruited to DNA DSBs - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-69891
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Pathway:R-GGA-69473] G2/M DNA damage checkpoint
(precedingEvent)	[Reaction:R-GGA-69608] Phosphorylation of CDC25A by CHEK2 [Reaction:R-GGA-5683774] p-T68-CHEK2 dimerizes
(inferredTo)	[Reaction:R-HSA-69891] Phosphorylation and activation of CHEK2 by ATM

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