Reactome | DHF is reduced to tetrahydrofolate (THF)

Schema > Reaction > Entries

DHF is reduced to tetrahydrofolate (THF) Show undefined attributes

catalystActivity	[CatalystActivity:10842872] folate reductase activity of DHFR2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10842876
displayName	DHF is reduced to tetrahydrofolate (THF)
eventOf	[Pathway:R-DME-196757] Metabolism of folate and pterines - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Drosophila melanogaster [Reaction:R-DME-197958] FPGS-2 transforms THF to THFPG - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-197972] DHF is reduced to tetrahydrofolate (THF) - Homo sapiens
input	[SimpleEntity:R-ALL-73604] DHF [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DHF is reduced to tetrahydrofolate (THF)
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-DME-197963] DHFR2 reduces FOLA to DHF - Drosophila melanogaster [Reaction:R-DME-9709098] DHFR dimer reduces FOLA to DHF - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-197972
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-DME-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix [Reaction:R-DME-197958] FPGS-2 transforms THF to THFPG
(inferredTo)	[Reaction:R-HSA-197972] DHF is reduced to tetrahydrofolate (THF)