Reactome | MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

Schema > Reaction > Entries

MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10891440] 5-formyltetrahydrofolate cyclo-ligase activity of MTHFS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10891442
displayName	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG
eventOf	[Pathway:R-DME-196757] Metabolism of folate and pterines - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-6803257] 5-formyl-THFPG [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG
output	[SimpleEntity:R-ALL-200640] 5,10-methenyl-THFPG [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6801342
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196757] Metabolism of folate and pterines
(inferredTo)	[Reaction:R-HSA-6801342] MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

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