Reactome | Mitochondrial FPGS-1 transforms THF to THFPG

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Mitochondrial FPGS-1 transforms THF to THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10843530] tetrahydrofolylpolyglutamate synthase activity of FPGS-1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10843532
displayName	Mitochondrial FPGS-1 transforms THF to THFPG
eventOf	[Pathway:R-DME-196757] Metabolism of folate and pterines - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-200682] Mitochondrial FPGS-1 transforms THF to THFPG - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] 6 × [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Mitochondrial FPGS-1 transforms THF to THFPG Conversion of mitochondrial THF to THF-polyglutamate
output	6 × [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] 6 × [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix] [SimpleEntity:R-ALL-200679] THFPG [mitochondrial matrix]
precedingEvent	[Reaction:R-DME-200680] SLC25A32 transports THF from cytosol to mitochondrial matrix - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-200682
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196757] Metabolism of folate and pterines
(inferredTo)	[Reaction:R-HSA-200682] Mitochondrial FPGS-1 transforms THF to THFPG

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