Reactome | SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

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SLC19A1 transports 5-methyl-THF from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10843502] folic acid transmembrane transporter activity of SLC19A1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10843504
displayName	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol
eventOf	[Pathway:R-DME-196757] Metabolism of folate and pterines - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-200709] 5-methyl-THF [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC19A1 transports 5-methyl-THF from extracellular region to cytosol Extracellular 5-methyltetrahydrofolate import across the plasma membrane
output	[SimpleEntity:R-ALL-200665] 5-methyl-THF [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-200652
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-DME-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG
(inferredTo)	[Reaction:R-HSA-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

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