Reactome | single mechanism MAP2K1/2 inhibitors [cytosol]

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single mechanism MAP2K1/2 inhibitors [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-CEL-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Caenorhabditis elegans [Reaction:R-DME-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Drosophila melanogaster [Reaction:R-GGA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Gallus gallus [Reaction:R-SSC-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Sus scrofa [Reaction:R-CFA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Canis familiaris [Reaction:R-RNO-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Rattus norvegicus [Reaction:R-MMU-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Mus musculus [Reaction:R-HSA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Homo sapiens [Reaction:R-BTA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Bos taurus
created	[InstanceEdit:9657573] Rothfels, Karen, 2019-08-08
dbId	9657574
disease	[Disease:1500689] cancer
displayName	single mechanism MAP2K1/2 inhibitors [cytosol]
hasCandidate	[ChemicalDrug:R-ALL-9657511] selumetinib [cytosol] [ChemicalDrug:R-ALL-9657553] PD 0325901 [cytosol] [ChemicalDrug:R-ALL-9657563] Cl-1040 [cytosol] [ChemicalDrug:R-ALL-9657523] pimasertib [cytosol] [ChemicalDrug:R-ALL-9657517] refametinib [cytosol]
hasMember	[ChemicalDrug:R-ALL-9657527] cobimetinib [cytosol] [ChemicalDrug:R-ALL-9657530] binimetinib [cytosol]
inDisease	true
name	single mechanism MAP2K1/2 inhibitors
schemaClass	CandidateSet
stId	R-ALL-9657574

Referrals

(input)	[Reaction:R-CEL-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-DME-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-GGA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-SSC-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-CFA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-RNO-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-MMU-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-HSA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-BTA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
(hasComponent)	[Complex:R-SSC-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-BTA-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-GGA-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-CFA-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-RNO-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-CEL-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-MMU-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-DME-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] [Complex:R-HSA-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane]
(activeUnit)	[NegativeRegulation:9657615] Negative regulation by 'activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane]'

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