Reactome | Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks

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Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9657605] Rothfels, Karen, 2019-08-08
dbId	9657606
displayName	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
eventOf	[Pathway:R-HSA-5674135] MAP2K and MAPK activation - Homo sapiens
input	[Complex:R-HSA-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [CandidateSet:R-ALL-9657574] single mechanism MAP2K1/2 inhibitors [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9657419] Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers [LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
orthologousEvent	[Reaction:R-DDI-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Dictyostelium discoideum [Reaction:R-CEL-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Caenorhabditis elegans [Reaction:R-DME-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Drosophila melanogaster [Reaction:R-GGA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Gallus gallus [Reaction:R-DRE-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Danio rerio [Reaction:R-SSC-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Sus scrofa [Reaction:R-BTA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Bos taurus [Reaction:R-CFA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Canis familiaris [Reaction:R-RNO-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Rattus norvegicus [Reaction:R-MMU-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Mus musculus
output	[Complex:R-HSA-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane]
precedingEvent	[Reaction:R-HSA-5672978] RAF phosphorylates MAP2K dimer - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9657606
summation	[Summation:9657172] Single mechanism MAP2K inhibitors bind to phosphorylated for...

Referrals

(hasEvent)

[Pathway:R-HSA-5674135] MAP2K and MAPK activation