Reactome | pimasertib [cytosol]

Schema > ChemicalDrug > Entries

candidateOf	[CandidateSet:R-ALL-9657574] single mechanism MAP2K1/2 inhibitors [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9657524] Rothfels, Karen, 2019-08-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9657523
disease	[Disease:1500689] cancer
displayName	pimasertib [cytosol]
inDisease	true
literatureReference	[LiteratureReference:9657245] Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo [LiteratureReference:9657388] MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy
maxDepth	1
name	pimasertib
referenceEntity	[ReferenceTherapeutic:iuphar.ligand:7872] pimasertib [Guide to Pharmacology:7872]
schemaClass	ChemicalDrug
stId	R-ALL-9657523

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