Reactome | Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks

Schema > Reaction > Entries

Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10546589
displayName	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
eventOf	[Pathway:R-SSC-5674135] MAP2K and MAPK activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Homo sapiens
input	[Complex:R-SSC-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [CandidateSet:R-ALL-9657574] single mechanism MAP2K1/2 inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
output	[Complex:R-SSC-9657587] activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane]
precedingEvent	[Reaction:R-SSC-5672978] RAF phosphorylates MAP2K dimer - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9657606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5674135] MAP2K and MAPK activation
(inferredTo)	[Reaction:R-HSA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks

Cite Us!