Reactome | O2 [extracellular region]

Schema > SimpleEntity > Entries

O2 [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-XTR-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] - Xenopus tropicalis [Complex:R-GGA-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] - Gallus gallus
consumedByEvent	[Reaction:R-CEL-5693681] DUOX1 reduces O2 to H2O2 - Caenorhabditis elegans [Reaction:R-DME-5693681] DUOX1 reduces O2 to H2O2 - Drosophila melanogaster [Reaction:R-GGA-5693681] DUOX1 reduces O2 to H2O2 - Gallus gallus [Reaction:R-XTR-5693681] DUOX1 reduces O2 to H2O2 - Xenopus tropicalis [Reaction:R-SSC-5693681] DUOX1 reduces O2 to H2O2 - Sus scrofa [Reaction:R-BTA-5693681] DUOX1 reduces O2 to H2O2 - Bos taurus [Reaction:R-MMU-5693681] DUOX1 reduces O2 to H2O2 - Mus musculus [Reaction:R-HSA-5693681] DUOX1 reduces O2 to H2O2 - Homo sapiens [Reaction:R-RNO-5693681] DUOX1 reduces O2 to H2O2 - Rattus norvegicus [Reaction:R-CFA-5693681] DUOX1 reduces O2 to H2O2 - Canis familiaris [Reaction:R-HSA-2002466] Formation of allysine by LOX - Homo sapiens [Reaction:R-HSA-2395340] Formation of hydroxyallysine by LOX - Homo sapiens [Reaction:R-HSA-9673797] NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen - Homo sapiens [Reaction:R-HSA-9673797] NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen - Homo sapiens [Reaction:R-GGA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Gallus gallus [Reaction:R-XTR-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Xenopus tropicalis [Reaction:R-DRE-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Danio rerio [Reaction:R-SSC-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Sus scrofa [Reaction:R-BTA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Bos taurus [Reaction:R-CFA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Canis familiaris [Reaction:R-MMU-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Mus musculus [Reaction:R-HSA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Homo sapiens [Reaction:R-RNO-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ - Rattus norvegicus [Reaction:R-GGA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Gallus gallus [Reaction:R-GGA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Gallus gallus [Reaction:R-DRE-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Danio rerio [Reaction:R-DRE-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Danio rerio [Reaction:R-SSC-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Sus scrofa [Reaction:R-SSC-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Sus scrofa [Reaction:R-CFA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Canis familiaris [Reaction:R-CFA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Canis familiaris [Reaction:R-RNO-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Rattus norvegicus [Reaction:R-RNO-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Rattus norvegicus [Reaction:R-MMU-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Mus musculus [Reaction:R-MMU-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Mus musculus [Reaction:R-HSA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Homo sapiens [Reaction:R-HSA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Homo sapiens [Reaction:R-GGA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Gallus gallus [Reaction:R-GGA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Gallus gallus [Reaction:R-XTR-5218841] NADPH oxidase 2 generates superoxide from oxygen - Xenopus tropicalis [Reaction:R-XTR-5218841] NADPH oxidase 2 generates superoxide from oxygen - Xenopus tropicalis [Reaction:R-DRE-5218841] NADPH oxidase 2 generates superoxide from oxygen - Danio rerio [Reaction:R-DRE-5218841] NADPH oxidase 2 generates superoxide from oxygen - Danio rerio [Reaction:R-SSC-5218841] NADPH oxidase 2 generates superoxide from oxygen - Sus scrofa [Reaction:R-SSC-5218841] NADPH oxidase 2 generates superoxide from oxygen - Sus scrofa [Reaction:R-BTA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Bos taurus [Reaction:R-BTA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Bos taurus [Reaction:R-CFA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Canis familiaris [Reaction:R-CFA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Canis familiaris [Reaction:R-RNO-5218841] NADPH oxidase 2 generates superoxide from oxygen - Rattus norvegicus [Reaction:R-RNO-5218841] NADPH oxidase 2 generates superoxide from oxygen - Rattus norvegicus [Reaction:R-MMU-5218841] NADPH oxidase 2 generates superoxide from oxygen - Mus musculus [Reaction:R-MMU-5218841] NADPH oxidase 2 generates superoxide from oxygen - Mus musculus [Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Homo sapiens [Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Homo sapiens [Reaction:R-GGA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Gallus gallus [Reaction:R-GGA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Gallus gallus [Reaction:R-DRE-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Danio rerio [Reaction:R-DRE-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Danio rerio [Reaction:R-SSC-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Sus scrofa [Reaction:R-SSC-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Sus scrofa [Reaction:R-BTA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Bos taurus [Reaction:R-BTA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Bos taurus [Reaction:R-CFA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Canis familiaris [Reaction:R-CFA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Canis familiaris [Reaction:R-RNO-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Rattus norvegicus [Reaction:R-RNO-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Rattus norvegicus [Reaction:R-MMU-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Mus musculus [Reaction:R-MMU-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Mus musculus [Reaction:R-HSA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Homo sapiens [Reaction:R-HSA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Homo sapiens [FailedReaction:R-HSA-5621402] Defective CP does not oxidise Fe2+ to Fe3+ - Homo sapiens [Reaction:R-GGA-5696131] AOC1 deaminates Hist - Gallus gallus [Reaction:R-XTR-5696131] AOC1 deaminates Hist - Xenopus tropicalis [Reaction:R-DRE-5696131] AOC1 deaminates Hist - Danio rerio [Reaction:R-BTA-5696131] AOC1 deaminates Hist - Bos taurus [Reaction:R-RNO-5696131] AOC1 deaminates Hist - Rattus norvegicus [Reaction:R-MMU-5696131] AOC1 deaminates Hist - Mus musculus [Reaction:R-HSA-5696131] AOC1 deaminates Hist - Homo sapiens [Reaction:R-GGA-5696146] AOC2 deaminates TYR - Gallus gallus [Reaction:R-SSC-5696146] AOC2 deaminates TYR - Sus scrofa [Reaction:R-BTA-5696146] AOC2 deaminates TYR - Bos taurus [Reaction:R-CFA-5696146] AOC2 deaminates TYR - Canis familiaris [Reaction:R-MMU-5696146] AOC2 deaminates TYR - Mus musculus [Reaction:R-HSA-5696146] AOC2 deaminates TYR - Homo sapiens [Reaction:R-GGA-5696183] AOC3 deaminates BZAM - Gallus gallus [Reaction:R-XTR-5696183] AOC3 deaminates BZAM - Xenopus tropicalis [Reaction:R-SSC-5696183] AOC3 deaminates BZAM - Sus scrofa [Reaction:R-BTA-5696183] AOC3 deaminates BZAM - Bos taurus [Reaction:R-CFA-5696183] AOC3 deaminates BZAM - Canis familiaris [Reaction:R-RNO-5696183] AOC3 deaminates BZAM - Rattus norvegicus [Reaction:R-MMU-5696183] AOC3 deaminates BZAM - Mus musculus [Reaction:R-HSA-5696183] AOC3 deaminates BZAM - Homo sapiens [Reaction:R-RNO-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Rattus norvegicus [Reaction:R-HSA-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Homo sapiens [Reaction:R-MMU-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Mus musculus [Reaction:R-CFA-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Canis familiaris [Reaction:R-BTA-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Bos taurus [Reaction:R-SSC-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Sus scrofa [Reaction:R-DRE-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Danio rerio [Reaction:R-XTR-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Xenopus tropicalis [Reaction:R-DDI-2160492] IL4I1:FAD oxidises L-Phe to kPPV - Dictyostelium discoideum [Reaction:R-MMU-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Mus musculus [Reaction:R-HSA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Homo sapiens [Reaction:R-RNO-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Rattus norvegicus [Reaction:R-CFA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Canis familiaris [Reaction:R-BTA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Bos taurus [Reaction:R-SSC-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Sus scrofa [Reaction:R-DRE-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Danio rerio [Reaction:R-XTR-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Xenopus tropicalis [Reaction:R-GGA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Gallus gallus [Reaction:R-CEL-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Caenorhabditis elegans [Reaction:R-MMU-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Mus musculus [Reaction:R-HSA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Homo sapiens [Reaction:R-RNO-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Rattus norvegicus [Reaction:R-CFA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Canis familiaris [Reaction:R-BTA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Bos taurus [Reaction:R-SSC-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Sus scrofa [Reaction:R-DRE-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Danio rerio [Reaction:R-XTR-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Xenopus tropicalis [Reaction:R-GGA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Gallus gallus [Reaction:R-CEL-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Caenorhabditis elegans
created	[InstanceEdit:352325] Jassal, Bijay, 2008-06-02
crossReference	[DatabaseIdentifier:29369] COMPOUND:C00007
dbId	352327
displayName	O2 [extracellular region]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9619952] Wu, G, 2018-09-19
name	O2 Oxygen dioxygen
negativelyRegulates	[NegativeRegulation:9839175] Negative regulation by 'O2 [extracellular region]'
producedByEvent	[Reaction:R-HSA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Homo sapiens [Reaction:R-MMU-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Mus musculus [Reaction:R-RNO-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Rattus norvegicus [Reaction:R-CFA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Canis familiaris [Reaction:R-BTA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Bos taurus [Reaction:R-SSC-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Sus scrofa [Reaction:R-DRE-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Danio rerio [Reaction:R-XTR-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Xenopus tropicalis [Reaction:R-GGA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Gallus gallus [Reaction:R-DDI-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Dictyostelium discoideum [Reaction:R-SPO-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Schizosaccharomyces pombe [Reaction:R-SCE-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Saccharomyces cerevisiae [Reaction:R-GGA-9709360] H2O2 reduces MetHb - Gallus gallus [Reaction:R-GGA-9709360] H2O2 reduces MetHb - Gallus gallus [Reaction:R-XTR-9709360] H2O2 reduces MetHb - Xenopus tropicalis [Reaction:R-XTR-9709360] H2O2 reduces MetHb - Xenopus tropicalis [Reaction:R-SSC-9709360] H2O2 reduces MetHb - Sus scrofa [Reaction:R-SSC-9709360] H2O2 reduces MetHb - Sus scrofa [Reaction:R-BTA-9709360] H2O2 reduces MetHb - Bos taurus [Reaction:R-BTA-9709360] H2O2 reduces MetHb - Bos taurus [Reaction:R-CFA-9709360] H2O2 reduces MetHb - Canis familiaris [Reaction:R-CFA-9709360] H2O2 reduces MetHb - Canis familiaris [Reaction:R-RNO-9709360] H2O2 reduces MetHb - Rattus norvegicus [Reaction:R-RNO-9709360] H2O2 reduces MetHb - Rattus norvegicus [Reaction:R-MMU-9709360] H2O2 reduces MetHb - Mus musculus [Reaction:R-MMU-9709360] H2O2 reduces MetHb - Mus musculus [Reaction:R-HSA-9709360] H2O2 reduces MetHb - Homo sapiens [Reaction:R-HSA-9709360] H2O2 reduces MetHb - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:15379] dioxygen [ChEBI:15379]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-352327
updateTrackers	[UpdateTracker:9891766] Update Tracker - [SimpleEntity:352327] O2 [extracellular region] - v52:[addName]

Referrals

(hasComponent)	[Complex:R-XTR-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] [Complex:R-MMU-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] [Complex:R-GGA-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] [Complex:R-CFA-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] [Complex:R-SSC-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] [Complex:R-BTA-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] [Complex:R-HSA-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region] [Complex:R-GGA-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-XTR-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-CFA-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-MMU-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-BTA-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-SSC-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-HSA-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-RNO-2168867] Hemoglobin alpha:ferroheme b:oxygen [extracellular region] [Complex:R-RNO-2168861] Hemoglobin beta:ferroheme b:oxygen [extracellular region]
(input)	[Reaction:R-HSA-2002466] Formation of allysine by LOX [Reaction:R-HSA-2395340] Formation of hydroxyallysine by LOX [FailedReaction:R-HSA-5621402] Defective CP does not oxidise Fe2+ to Fe3+ [Reaction:R-GGA-5696131] AOC1 deaminates Hist [Reaction:R-XTR-5696131] AOC1 deaminates Hist [Reaction:R-DRE-5696131] AOC1 deaminates Hist [Reaction:R-BTA-5696131] AOC1 deaminates Hist [Reaction:R-RNO-5696131] AOC1 deaminates Hist [Reaction:R-MMU-5696131] AOC1 deaminates Hist [Reaction:R-HSA-5696131] AOC1 deaminates Hist [Reaction:R-GGA-5696146] AOC2 deaminates TYR [Reaction:R-SSC-5696146] AOC2 deaminates TYR [Reaction:R-BTA-5696146] AOC2 deaminates TYR [Reaction:R-CFA-5696146] AOC2 deaminates TYR [Reaction:R-MMU-5696146] AOC2 deaminates TYR [Reaction:R-HSA-5696146] AOC2 deaminates TYR [Reaction:R-GGA-5696183] AOC3 deaminates BZAM [Reaction:R-XTR-5696183] AOC3 deaminates BZAM [Reaction:R-SSC-5696183] AOC3 deaminates BZAM [Reaction:R-BTA-5696183] AOC3 deaminates BZAM [Reaction:R-CFA-5696183] AOC3 deaminates BZAM [Reaction:R-RNO-5696183] AOC3 deaminates BZAM [Reaction:R-MMU-5696183] AOC3 deaminates BZAM [Reaction:R-HSA-5696183] AOC3 deaminates BZAM [Reaction:R-HSA-9673797] NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen [Reaction:R-GGA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-XTR-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-DRE-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-SSC-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-BTA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-CFA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-MMU-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-HSA-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-RNO-8956458] RNLS:FAD oxidises dh-beta-NAD to NAD+ [Reaction:R-GGA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-DRE-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-SSC-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-CFA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-RNO-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-MMU-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-HSA-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-GGA-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-XTR-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-DRE-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-SSC-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-BTA-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-CFA-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-RNO-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-MMU-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen [Reaction:R-GGA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-DRE-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-SSC-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-BTA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-CFA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-RNO-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-MMU-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-HSA-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen [Reaction:R-CEL-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-DME-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-GGA-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-XTR-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-SSC-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-BTA-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-RNO-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-HSA-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-MMU-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-CFA-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-BTA-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-SSC-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-DRE-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-XTR-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-DDI-2160492] IL4I1:FAD oxidises L-Phe to kPPV [Reaction:R-MMU-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-HSA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-RNO-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-CFA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-BTA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-SSC-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-DRE-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-XTR-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-GGA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-CEL-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ [Reaction:R-MMU-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-HSA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-RNO-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-CFA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-BTA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-SSC-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-DRE-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-XTR-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-GGA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-CEL-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ [Reaction:R-MMU-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-HSA-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-RNO-5693681] DUOX1 reduces O2 to H2O2 [Reaction:R-CFA-5693681] DUOX1 reduces O2 to H2O2
(output)	[Reaction:R-GGA-9709360] H2O2 reduces MetHb [Reaction:R-XTR-9709360] H2O2 reduces MetHb [Reaction:R-SSC-9709360] H2O2 reduces MetHb [Reaction:R-BTA-9709360] H2O2 reduces MetHb [Reaction:R-CFA-9709360] H2O2 reduces MetHb [Reaction:R-RNO-9709360] H2O2 reduces MetHb [Reaction:R-MMU-9709360] H2O2 reduces MetHb [Reaction:R-HSA-9709360] H2O2 reduces MetHb [Reaction:R-HSA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-MMU-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-RNO-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-CFA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-BTA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-SSC-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-DRE-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-XTR-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-GGA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-DDI-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-SPO-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Reaction:R-SCE-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)
(regulator)	[NegativeRegulation:9839175] Negative regulation by 'O2 [extracellular region]'
(updatedInstance)	[UpdateTracker:9891766] Update Tracker - [SimpleEntity:352327] O2 [extracellular region] - v52:[addName]

© 2026 Reactome

Cite Us!