Reactome | H2O2 reduces MetHb

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H2O2 reduces MetHb Show undefined attributes

authored	[InstanceEdit:9708955] Stephan, Ralf, 2020-12-03
category	dissociation
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9709348] Stephan, Ralf, 2020-12-14
dbId	9709360
displayName	H2O2 reduces MetHb
edited	[InstanceEdit:9708955] Stephan, Ralf, 2020-12-03
eventOf	[Pathway:R-HSA-9707564] Cytoprotection by HMOX1 - Homo sapiens
followingEvent	[Reaction:R-HSA-9709317] CO binds to free ferrohemoglobin - Homo sapiens
input	4 × [SimpleEntity:R-ALL-351629] H2O2 [extracellular region] [Complex:R-HSA-2168866] MetHb [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9709427] Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	H2O2 reduces MetHb
orthologousEvent	[Reaction:R-GGA-9709360] H2O2 reduces MetHb - Gallus gallus [Reaction:R-XTR-9709360] H2O2 reduces MetHb - Xenopus tropicalis [Reaction:R-SSC-9709360] H2O2 reduces MetHb - Sus scrofa [Reaction:R-BTA-9709360] H2O2 reduces MetHb - Bos taurus [Reaction:R-CFA-9709360] H2O2 reduces MetHb - Canis familiaris [Reaction:R-RNO-9709360] H2O2 reduces MetHb - Rattus norvegicus [Reaction:R-MMU-9709360] H2O2 reduces MetHb - Mus musculus
output	[Complex:R-HSA-9707672] ferrohemoglobin [extracellular region] 4 × [SimpleEntity:R-ALL-109276] H2O [extracellular region] 2 × [SimpleEntity:R-ALL-352327] O2 [extracellular region]
precedingEvent	[Reaction:R-HSA-9707504] H2O2 oxidises ferrohemoglobin to MetHb - Homo sapiens [BlackBoxEvent:R-HSA-9709396] CO translocates from cytosol to extracellular region - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9709360
summation	[Summation:9709345] Hydrogen peroxide (H2O2) can reduce methemoglobin (metHb) bu...

Referrals

(precedingEvent)	[Reaction:R-HSA-9709317] CO binds to free ferrohemoglobin [NegativePrecedingEvent:9767162] Futile Cycle: H2O2 reduces MetHb
(hasEvent)	[Pathway:R-HSA-9707564] Cytoprotection by HMOX1