Reactome | NADPH oxidase 2 generates superoxide from oxygen

Schema > Reaction > Entries

NADPH oxidase 2 generates superoxide from oxygen Show undefined attributes

catalystActivity	[CatalystActivity:10512116] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC1:GTP [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10512118
displayName	NADPH oxidase 2 generates superoxide from oxygen
eventOf	[Pathway:R-SSC-5668599] RHO GTPases Activate NADPH Oxidases - Sus scrofa [Pathway:R-SSC-4420097] VEGFA-VEGFR2 Pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-352327] O2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	NADPH oxidase 2 generates superoxide from oxygen
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-3299686] O2.- [extracellular region]
precedingEvent	[Reaction:R-SSC-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5218841
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5668599] RHO GTPases Activate NADPH Oxidases [Pathway:R-SSC-4420097] VEGFA-VEGFR2 Pathway
(inferredTo)	[Reaction:R-HSA-5218841] NADPH oxidase 2 generates superoxide from oxygen

Cite Us!