Reactome | SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+

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SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ Show undefined attributes

catalystActivity	[CatalystActivity:10022508] ferroxidase activity of SLC40A1:HEPH:6Cu2+ [plasma membrane]
category	transition
compartment	[Compartment:947586] external side of plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10022510
displayName	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+
eventOf	[Pathway:R-MMU-917937] Iron uptake and transport - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-917888] apoTF binds 2Fe3+ to form holoTF - Mus musculus
inferredFrom	[Reaction:R-HSA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Homo sapiens
input	4 × [SimpleEntity:R-ALL-435347] Fe2+ [extracellular region] 4 × [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-352327] O2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ Oxidation of Fe2+ by hephaestin
output	4 × [SimpleEntity:R-ALL-912516] Fe3+ [extracellular region] 2 × [SimpleEntity:R-ALL-109276] H2O [extracellular region]
precedingEvent	[Reaction:R-MMU-442368] SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-917933
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-MMU-917888] apoTF binds 2Fe3+ to form holoTF
(inferredTo)	[Reaction:R-HSA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+

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