Reactome | DUOX1 reduces O2 to H2O2

Schema > Reaction > Entries

DUOX1 reduces O2 to H2O2 Show undefined attributes

catalystActivity	[CatalystActivity:10522336] NAD(P)H oxidase H2O2-forming activity of p-DUOX1:DUOXA1:TPO:CAV1:TXNDC11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10522338
displayName	DUOX1 reduces O2 to H2O2
eventOf	[Pathway:R-SSC-209968] Thyroxine biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8855490] Lactoperoxidase (LPO) produces OSCN- - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:161936] hydrogen peroxide biosynthetic process
inferredFrom	[Reaction:R-HSA-5693681] DUOX1 reduces O2 to H2O2 - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-351627] NADPH [extracellular region] [SimpleEntity:R-ALL-352327] O2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	DUOX1 reduces O2 to H2O2
output	[SimpleEntity:R-ALL-351629] H2O2 [extracellular region] [SimpleEntity:R-ALL-351628] NADP+ [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5693681
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-209968] Thyroxine biosynthesis
(precedingEvent)	[Reaction:R-SSC-8855490] Lactoperoxidase (LPO) produces OSCN-
(inferredTo)	[Reaction:R-HSA-5693681] DUOX1 reduces O2 to H2O2