Reactome | kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O

Schema > Reaction > Entries

kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O Show undefined attributes

catalystActivity	[CatalystActivity:11081487] kynurenine 3-monooxygenase activity of KMO [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11081489
displayName	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
eventOf	[Pathway:R-SCE-71240] Tryptophan catabolism - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-9972889] AADAT transaminates 3HKYN to xanthurenate - Saccharomyces cerevisiae [Reaction:R-SCE-71217] 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+ - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29970] L-KYN [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)
output	[SimpleEntity:R-ALL-34351] 3HKYN [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-71200
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-71240] Tryptophan catabolism
(precedingEvent)	[Reaction:R-SCE-9972889] AADAT transaminates 3HKYN to xanthurenate [Reaction:R-SCE-71217] 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+
(inferredTo)	[Reaction:R-HSA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O

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