Reactome | PXLP-KYAT1 dimer transaminates L-KYN to KYNA

Schema > Reaction > Entries

PXLP-KYAT1 dimer transaminates L-KYN to KYNA Show undefined attributes

catalystActivity	[CatalystActivity:10942779] kynurenine-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10942781
displayName	PXLP-KYAT1 dimer transaminates L-KYN to KYNA
eventOf	[Pathway:R-CEL-71240] Tryptophan catabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29970] L-KYN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-KYAT1 dimer transaminates L-KYN to KYNA L-kynurenine + 2-oxoglutarate => kynurenate + L-glutamate + H2O
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-893587] KYNA [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
regulatedBy	[NegativeRegulation:R-HSA-2160520] Negative regulation by 'L-Phe [cytosol]' [NegativeRegulation:R-HSA-8939578] Negative regulation by 'I3LACT, I3PROPA [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-893596
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-71240] Tryptophan catabolism
(inferredTo)	[Reaction:R-HSA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA

Cite Us!