Reactome | AUP1 [endoplasmic reticulum membrane]

AUP1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9921611

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser for interactor UniProt:P13569 CFTR

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External Reference Information

External Reference

UniProt:Q9Y679 AUP1

Gene Names

AUP1

Chain

chain:1-410

Reference Genes

BioGPS Gene:550 AUP1

COSMIC - genes:AUP1 AUP1

CTD Gene:550 AUP1

dbSNP Gene:550 AUP1

ENSEMBL:ENSG00000115307 AUP1

HGNC:891 AUP1

KEGG:hsa:550 AUP1

Monarch:550 AUP1

NCBI Gene:550 AUP1

OMIM:602434 AUP1

UCSC:Q9Y679 AUP1

Reference Transcript

Other Identifiers

11756564_a_at

11761859_a_at

11761860_x_at

16899335

220525_PM_s_at

220525_s_at

2560251

2560252

2560253

2560255

2560256

2560257

2560258

2560259

2560260

2560261

2560262

2560263

2560264

2560265

2560266

2560267

2560268

2560269

2560270

2560271

2560272

2560273

2560274

2560275

2560276

2560277

2560278

2560279

2560280

2560281

2560282

2560283

2560284

2560285

44750_at

550

8053214

A_23_P253421

GE61563

GE81752

GE88817

GO:0005515

GO:0005773

GO:0005776

GO:0005783

GO:0005789

GO:0005811

GO:0006886

GO:0009615

GO:0016020

GO:0030163

GO:0030970

GO:0031410

GO:0031624

GO:0031625

GO:0034389

GO:0036503

GO:0043130

GO:0043226

GO:0061724

GO:0070062

GO:0140042

GO:1990044

HMNXSV003018037

ILMN_1651378

PH_hs_0019545

TC02002001.hg

g6912259_3p_a_at

Participates

as a component of

NS4A:AUP1 [endoplasmic reticulum membrane] (Homo sapiens)

as an input of

NS4A binds AUP1 (Homo sapiens)

Cross References

RefSeq

XP_054198661.1, NP_853553.1

ENSEMBL

ENST00000377526, ENSP00000366748, ENSP00000403430, ENST00000425118, ENSG00000115307

OpenTargets

ENSG00000115307

GeneCards

AUP1

HPA

ENSG00000115307-AUP1

PRO

Q9Y679

Pharos - Targets

Q9Y679

PDB

2EKF, 7LEW

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60604 UBE2G2	2	Ub-C89-UBE2G2 [cytosol] (R-HSA-8864195) UBE2G2 [cytosol] (R-HSA-947640)	0.75	7
UniProt:P04114 APOB	20	APOB(28-2179) [cytosol] (R-HSA-2395786) APOB(28-2179) [early endosome] (R-HSA-2429651) APOB(28-4563) [lysosomal lumen] (R-HSA-8876369) APOB(28-2179) [endosome lumen] (R-HSA-174716) APOB(28-2179) [endosome membrane] (R-HSA-174762) APOB(28-4563) [plasma membrane] (R-HSA-171089) APOB(28-4563) [clathrin-coated endocytic vesicle membrane] (R-HSA-171155) APOB(28-4563) [endosome lumen] (R-HSA-171119) APOB(28-4563) [endosome membrane] (R-HSA-171121) APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (R-HSA-174788) APOB(28-2179) [plasma membrane] (R-HSA-174625) APOB(28-4563) [extracellular region] (R-HSA-171065) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [extracellular region] (R-HSA-2173702) APOB(28-4563) [endoplasmic reticulum membrane] (R-HSA-6784882) p-APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-8957068) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239461) AcK-APOB(28-4563) [extracellular region] (R-HSA-2173751) AcK-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239446) APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2512789) APOB(28-4563) [smooth endoplasmic reticulum] (R-HSA-8866317)	0.612	5
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.597	8
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.581	4
UniProt:Q9HC97 GPR35	1	GPR35 [plasma membrane] (R-HSA-3295332)	0.547	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.527	5
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	8

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