Regulation of PD-L1(CD274) translation

Stable Identifier
R-HSA-9909620
DOI
10.3180/R-HSA-9909620.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Regulation of PD-L1(CD274) translation
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The synthesis of PD-L1 (CD274) protein from its mRNA under various physiological and pathological conditions is tightly regulated by microRNAs (miRNAs) that bind to the 3' untranslated region (3' UTR) of PD-L1 mRNA, influencing its stability and translation efficiency (Skafi et al., 2020, Wang et al., 2017). For example, miR 34a and miR 200 directly target PD L1 mRNA, leading to decreased protein synthesis, which is important in controlling autoimmune response in normal physiological conditions and immune escape mechanisms in cancer (Danbaran et al., 2020, Kao et al., 2017, Grenda et al., 2017). The translation regulation of PD-L1 is a critical area of research, particularly in the context of cancer and other diseases where PD-L1 is implicated in pathology (Zhou et al., 2023, Ashrafizadeh et al., 2020).
Literature References
PubMed ID Title Journal Year
28675453 New Dancing Couple: PD-L1 and MicroRNA

Grenda, A, Krawczyk, P

Scand J Immunol 2017
28629895 Tumor Suppressor microRNAs Contribute to the Regulation of PD-L1 Expression in Malignant Pleural Mesothelioma

Kao, SC, Cheng, YY, Williams, M, Kirschner, MB, Madore, J, Lum, T, Sarun, KH, Linton, A, McCaughan, B, Klebe, S, van Zandwijk, N, Scolyer, RA, Boyer, MJ, Cooper, WA, Reid, G

J Thorac Oncol 2017
32416456 How microRNAs affect the PD-L1 and its synthetic pathway in cancer

Danbaran, GR, Aslani, S, Sharafkandi, N, Hemmatzadeh, M, Hosseinzadeh, R, Azizi, G, Jadidi-Niaragh, F, Babaie, F, Mohammadi, H

Int Immunopharmacol 2020
32544493 Immunomodulatory role for MicroRNAs: Regulation of PD-1/PD-L1 and CTLA-4 immune checkpoints expression

Skafi, N, Fayyad-Kazan, M, Badran, B

Gene 2020
32504749 PD-1/PD-L1 axis regulation in cancer therapy: The role of long non-coding RNAs and microRNAs

Ashrafizadeh, M, Zarrabi, A, Hushmandi, K, Zarrin, V, Moghadam, ER, Zabolian, A, Tavakol, S, Samarghandian, S, Najafi, M

Life Sci 2020
29186904 The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint

Wang, Q, Lin, W, Tang, X, Li, S, Guo, L, Lin, Y, Kwok, HF

Int J Mol Sci 2017
37228770 PD-L1: expression regulation

Zhou, YJ, Li, G, Wang, J, Liu, M, Wang, Z, Song, Y, Zhang, X, Wang, X

Blood Sci 2023
Participants
Events
Participates
as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-05-14)
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