CD274 mRNA binds miR-Let7-a1 RISC

Stable Identifier
R-HSA-9925246
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CD274 mRNA binds miR-Let7-a1 RISC
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MicroRNA-Let7a (miR-Let7a) is expressed in a wide variety of cells (microglia, macrophages, endothelial cells) and known to play a role in regulating aspects of innate immune response, autophagy and viral infection (Ueta et al., 2023, Song et al, 2015, Letafati et al., 2022). It regulates expression of CD274 (PD-L1) by directing binding to the 3’UTR of the PDL1 mRNA and inhibits its expression by inhibiting its translation (Chen et al., 2019 and Hong et al., 2020)
Literature References
PubMed ID Title Journal Year
30651289 LIN28/let-7/PD-L1 Pathway as a Target for Cancer Immunotherapy

Chen, Y, Xie, C, Zheng, X, Nie, X, Wang, Z, Liu, H, Zhao, Y

Cancer Immunol Res 2019
32746878 Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)

Hong, W, Xue, M, Jiang, J, Zhang, Y, Gao, X

J Exp Clin Cancer Res 2020
Participants
Input
Output
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as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-10-16)
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